Margaret, Vice President and Head of Quality at Marengo Therapeutics, brings our team an impressive thirty-three years of pharmaceutical and biotech experience. For the past twenty-nine years, she has been a dedicated advocate for quality, with a particular focus on GxP regulations. Her expertise has led to the successful development and implementation of quality strategies, ensuring our compliance. Margaret’s belief in tailored systems that meet our company’s needs is a testament to her understanding of our unique challenges and goals.

Over the past six years, Margaret has led GxP Quality for two early clinical phase biotech companies, overseeing the implementation of electronic quality management systems. She has supported these companies in non-clinical studies, GLP studies, clinical protocol development, GMP manufacturing and testing, and preparation of IND filings. Before her role at Marengo, Margaret served as Inspection Lead at Shire, managing site readiness for regulatory agency inspections. She also led compliance programs at Sanofi and managed audit and recall programs at Takeda.

Margaret earned her B.S. in Biology, specializing in microbiology and biotechnology. She has continued her education with business studies, completing the Harvard Manage Mentor series and QP coursework. Additionally, Margaret has completed Operational Excellence and Lean Six Sigma Green Belt programs. Margaret’s extensive experience and collaborative nature will lead the Marengo team to the next level of quality and compliance.

As CEO of Marengo Therapeutics and a director of the company’s board, Zhen Su brings nearly three decades of experience as a physician-scientist and biopharma executive, with expertise in building and leading both R&D and commercial organizations. During his tenure at Marengo, Zhen has led the team’s progressing the company’s lead asset into clinical trials, grown its leading-edge pipeline, and established a $2.8B strategic partnership with Ipsen. Zhen is also the Founding Chair for the Biotech Committee of the Society for Immunotherapy of Cancer (SITC) and was recently appointed to the Board of Directors at Karyopharm Therapeutics Inc (NASDAQ: KPTI), CytomX Therapeutics (NASDAQ: CTMX) and Galvanize Therapeutics.

Prior to joining Marengo, Zhen served as Senior Vice President and Global Head of Oncology Business Francise for Merck KGaA, where he led the franchise’s turnaround to achieve double-digit organic growth and an annual revenue above $1B. In this role, he also successfully expanded the oncology portfolio including key alliance partnerships with Pfizer ($2.8B), GSK ($4.2B), and Debiopharm ($1.1B). In his earlier role as Chief Medical Officer of EMD Serono, he played an instrumental role in 8 major regulatory approvals across different therapeutic areas across Oncology and Neurology for Bavencio^®, Tepmetko^®, Erbitux^®, and Mavenclad^®. He also held leadership roles with increasing responsibilities at Sanofi Oncology for Taxotere^® and Jevtana^® and GlaxoSmithKline in Oncology, Respiratory and Urology.

Before his industry career, Zhen served on the faculty of Duke University Medical School as an Assistant Professor, where he led early clinical studies focusing on mRNA-based and cell-based immunotherapy in Oncology, and then the University of Florida, where he was the director of the Cell and Gene Therapy program. He is the author of more than 60 publications in immuno-oncology and targeted oncology.

Zhen earned his M.D. from the Technical University of Dresden, completed his post-doctoral training in Cancer Immunotherapy at Duke University Medical Center, and received an MBA from the University of Toronto.

As Senior Strategic Advisor to Marengo Therapeutics, Dr. Chabner brings decades of extensive experience pioneering key research in the field of cancer drug discovery and development. In addition to his role at Marengo, he is an Allen Distinguished Investigator, Clinical Director Emeritus for the Massachusetts General Hospital Cancer Center, and a Professor of Medicine at Harvard Medical School. During his career at the National Cancer Institute, he served as a Senior Investigator in the Laboratory of Chemical Pharmacology, Chief of the Clinical Pharmacology Branch, Director of the Clinical Oncology Program, and Director of the Division of Cancer Treatment. At the NCI, he maintained an active laboratory program in cancer pharmacology, where he led the development of the breast cancer drug Taxol. His research contributed significantly to the development of high dose chemotherapy regimens, and to standard therapies for lymphoma. Dr. Chabner is a senior editor for The Oncologist and in 2006, he received a presidential appointment to the National Cancer Advisory Board at the NCI.

Dr. Chabner received his M.D. from Harvard Medical School.

Dr Elena Garralda is a Medical Oncologist, Principal Investigator and Researcher. Currently the Director of Early Drug Development and Co-director of the Clinical Research Program at VHIO. Dedicated to translational research, she coordinates the phase I program and the clinical research program, where complex clinical trials with drugs in early development (phase I and early phase II) focus on targeted agents and immunotherapies, with special emphasis in cell signaling, cancer stem cells, immuno-oncology and first-in-human studies of targeted therapies, rational combinations, and biomarker-driven trials. Dr Garralda is chair of ESMO’s Early Drug Development Track, member of ENA’s Scientific Committee, faculty of the “Methods in Clinical Cancer Research” annual workshop, chair of EORTC’s RECIST Task Force and the Clinical Trials leader for the Cancer Core Europe Consortium among other working groups and associations. She has authored over 100 articles published in peer-reviewed journals including Journal of Clinical Oncology, Nature Medicine and New England Journal of Medicine, has presented more than 150 abstracts and posters in international congresses as AACR, ESMO, ASCO, TAT or ENA, and serves as reviewer for JAMA Oncology, Annals of Oncology, Cancer Treatment Reviews, British Journal of Cancer, Clinical Cancer Research, Lancet Oncology, Nature Reviews or ESMO Open among others.

Dr. E. John Wherry is the Chair of the Department of Systems Pharmacology and Translational Therapeutics in the Perelman School of Medicine, Director of the UPenn Institute for Immunology, and the Barbara and Richard Schiffrin President’s Distinguished Professor. He has helped pioneer the field of T cell exhaustion, assisting in identifying the role of the “checkpoint” molecule PD-1 and others for reinvigoration of exhausted T cells in cancer and defining the underlying molecular and epigenetic mechanisms of exhausted T cells. He has received numerous honors in his career, including the Distinguished Alumni award from the Thomas Jefferson University, the Cancer Research Institute’s Frederick W. Alt Award for New Discoveries in Immunology, and the Stanley N. Cohen Biomedical Research Award from the University of Pennsylvania Perelman School of Medicine. Dr. Wherry received his PhD from Thomas Jefferson University.

Dr. Lillian Siu has over 20 years of experience as a senior medical oncologist at Princess Margaret Cancer Centre, as well as experience as a Professor of Medicine at the University of Toronto. Dr. Siu’s main research focus is in precision oncology, biomarkers especially circulating tumor DNA and clinical trials methodology. She is the Director of the Phase I Program, Co-Director of the Bras and Family Drug Development Program, and Clinical Lead for the Tumor Immunotherapy Program at Princess Margaret Cancer Centre. Dr. Siu is currently the Editor-in-Chief for American Association for Cancer Research’s newest journal Cancer Research Communications. She is also a scientific editor for Cancer Discovery and is on the editorial board for JAMA Oncology, Cell and Cancer Cell. Dr. Siu earned her MD from the University of Toronto.

Dr. Howard Kaufman has over 25 years of experience in cancer immunotherapy and drug development. Previously, he served as a Society for Immunotherapy of Cancer (SITC) President and is currently the President and Chief Executive Officer at Ankyra Therapeutics. In addition, he served as a Clinical Associate at Massachusetts General Hospital. His research focuses on developing oncolytic viruses and immunotherapy for the treatment of melanoma and other cutaneous malignancies. His work has led to the FDA approval of the first oncolytic virus in cancer treatment, and established the importance of anti-PD-L1 treatment for advanced Merkel cell carcinoma. His lab continues to advance our understanding of how viruses induce immunogenic cell death and initiate host anti-tumor immunity. Dr. Kaufman earned his MD from Loyola University Chicago.

Dr. Aurélien Marabelle is a physician scientist who brings expertise in oncology and immunology to Marengo. He currently is Director of the Clinical Investigation Center BIOTHERIS focusing on intratumoral immunotherapies, full professor of Clinical Immunology at the University of Paris Saclay, and leader of a translational research laboratory within the National Institute of Health and Medical Research (INSERM), focusing on mechanisms of action of immune targeted therapies. He also leads a clinical practice dedicated to early phase clinical trials of cancer immunotherapies within the Drug Development Department of the Gustave Roussy Cancer Center in France. He is the current President of the French Society for Cancer Immunotherapies. Dr. Marabelle earned his PhD in Oncology and Immunology at Ecole Normale Supérieure de Lyon, King’s College London, and University of Lyon. He trained at the University of Paris VI medical school and received his M.D. from the University of Clermont-Ferrand.

Dr. Everett E. Vokes, MD is an internationally renowned expert with over 40 years of experience in the treatment of head and neck and lung cancers. Currently, he serves as the John E. Ultmann Distinguished Service Professor of Medicine, Chair for the Department of Medicine, and Physician-in-Chief at the University of Chicago, where he leads the Department of Medicine’s focus on the discovery and delivery of personalized medicine. From 2021-2022, he served as the President of the American Society of Clinical Oncology (ASCO). Dr. Vokes is a widely published author with over 450 papers and 80 book chapters, has served on numerous advisory committees and editorial boards, and has received many awards, including the ASCO Translational Research Professorship and recognition as a “Giant of Cancer Care”. Dr. Vokes completed his medical degree at the University of Bonn Medical School and residency in internal medicine at Ravenswood Hospital Medical Center in Chicago and at the University of Southern California in Los Angeles. 

Josep Tabernero is a distinguished expert in medical oncology currently serving as the Director of Vall d’Hebron Institute of Oncology (VHIO) and Head of the Medical Oncology Department at Vall d’Hebron University Hospital. His research centers on molecular targeted therapies, targeting specific oncoproteins and novel immunotherapies to advance and accelerate more effective personalized cancer medicines for patients displaying genetic lesions or pathway dysregulation. He has expertise in predictive markers of response to anti-cancer therapies and innovative preclinical models (patient-derived xenografts and organoids) for studying tumor development. Josep served as President of the European Society for Medical Oncology (ESMO) from 2018-2019 and has been an active member of its Executive Board and multiple educational and scientific committees across ESMO, AACR, and ASCO. He actively contributes to various scientific committees and prestigious journals, driving progress in oncology globally. He is the Chair of Cancer Core Europe and a member of the Board of Directors of the Organisation of European Cancer Institutes (OECI).