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Tissue agnostic Antigen Rich Tumors in PD1 Resistant Population
Additional solid tumors
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Partnered with
Cold tumors
Cold tumors
Partnered with
STAR0602 is Marengo’s first T cell activator generated from Marengo’s STAR platform that provides a ‘dual boost’ to elevate T cells function and response to tumors. STAR0602 acts on a broad range of tumor antigen-specific Vβ6/10 T cells which are prevalent across many common cancer types (approx. 10-12% of TILs in each common cancer). By combining a novel non-clonal mode of TCR activation with a T cell co-stimulator delivered to the same T cells, it promotes the expansion of a new population of clonally diverse, effector memory Vβ 6/10 T cells that turbo-charges the anti-tumor immune response and promotes durable clearance of cancer cells. STAR0602 has undergone extensive preclinical testing, which demonstrates potent anti-tumor activity in both mouse and human ex vivo tumor models attributed to a distinct mechanism of action from existing cancer immunotherapies.
START-001 is a Phase I/II clinical trial evaluating the safety, tolerability, and preliminary clinical activity of STAR0602 as a single agent in biomarker selected patients with advanced antigen-rich solid tumors including PD-1 refractory and rare tumors. This open-label, multi-center trial consists of two parts: Phase I dose escalation and Phase II dose expansion.
For more information, please visit clinicaltrials.gov (trial identifier: NCT05592626).
For patients interested in enrolling in this study contact: kliu@marengotx.com
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